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You may have heard about it: Lorcaserin for losing weight. Your next question will surely be something like this: Is Lorcaserin effective for losing weight?

Lorcaserin may be the next big thing after sibutramine said “goodbye” to the weight loss market. According to a study a recent study funded by  Arena Pharmaceuticals, conducted by a group of researchers from MedStar Health Research Institute at Washington Hospital Center, and published in the July 2011 issue of The Journal of Clinical Endocrinology and Metabolism, lorcaserin together with a healthy diet and lifestyle can result in more significant weight loss compared to placebo.

Lorcaserin is a serotonin 2C receptor agonist, a chemical compound that mimics serotonin. Serotonin is a chemical found in the nerve endings that causes a decrease in appetite.

In this particular study, the researchers recruited 2008 patients with the body mass index of 30 to 45 kilograms per m2 belonging to the age range of 18 to 65 years old. The subjects were randomly assigned to lorcaserin 10mg twice per day, lorcaserin 10mg once per day, or placebo. All of them received the same diet and exercise counseling. What are their findings? A significantly greater weight reduction was observed in subjects who received lorcaserin compared to those who received the placebo. The most common adverse effects of this weight loss drug include headache, dizziness, and nausea.


The Journal of Clinical Endocrinology and Metabolism; A One-Year Randomized Trial of Lorcaserin for Weight Loss in Obese and Overweight Adults: The BLOSSOM Trial; Fidler, M.C. et al.; July 2011

Category : News

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